Human anti-SARS-CoV & CoV-2 Spike Antibody (IgM), clone CR3022
Human anti-SARS-CoV-2 Spike antibody [CR3022] recognize human SARS-CoV
and CoV-2 Spike protein with high affinity. The binding site is amino acids 318-
510 (RBD, Receptor Binding Domain) in the S1 subunit of the Spike protein.
Coronavirus Spike protein conducts the process that interacting with cellular
receptor and membrane fusion to allow virus entering into target cells. Spike
protein also can be used to define specificity of the virus, and be used as key
target for vaccine design. The glycosylated Spike protein can be detected in the
virus-infected cell and cell culture medium. The RBD is responsible for
recognizing the cell surface receptor.
and CoV-2 Spike protein with high affinity. The binding site is amino acids 318-
510 (RBD, Receptor Binding Domain) in the S1 subunit of the Spike protein.
Coronavirus Spike protein conducts the process that interacting with cellular
receptor and membrane fusion to allow virus entering into target cells. Spike
protein also can be used to define specificity of the virus, and be used as key
target for vaccine design. The glycosylated Spike protein can be detected in the
virus-infected cell and cell culture medium. The RBD is responsible for
recognizing the cell surface receptor.
Product type:
Recombinant Human IgM, clone CR3022
Concentration:
0.5 mg/mL
Reactivity:
SARS-CoV & CoV-2
Isotype:
IgM
Form:
Liquid
Storage buffer:
Phosphate Buffered Saline pH 7.4.
Storage:
Store at 4°C for six months.
Application:
ELISA, NTRL, SPR, Crystallography
Manual:
Note: Application concentration may be various determined by the end user.
References:
1. ter Meulen J, van den Brink EN, Poon LL, et al. Human monoclonal antibody combination agains t SARS coronavir us: synergy and cove rage of escape mutants. PLoS Med. 2006;3(7): e237.
2. Yuan M, Wu NC, Zhu X, et al. A highly conserved cryptic epitope in the receptor binding domains of SARS CoV 2 and SARS CoV. Science. 2020;eabb7269.
Recombinant Human IgM, clone CR3022
Concentration:
0.5 mg/mL
Reactivity:
SARS-CoV & CoV-2
Isotype:
IgM
Form:
Liquid
Storage buffer:
Phosphate Buffered Saline pH 7.4.
Storage:
Store at 4°C for six months.
Application:
ELISA, NTRL, SPR, Crystallography
Manual:
| Application | Dilution factor |
| ELISA | 1:5000-20000 |
| NTRL | Assay dependent |
| SPR | Assay dependent |
| Crystallography | Assay dependent |
References:
1. ter Meulen J, van den Brink EN, Poon LL, et al. Human monoclonal antibody combination agains t SARS coronavir us: synergy and cove rage of escape mutants. PLoS Med. 2006;3(7): e237.
2. Yuan M, Wu NC, Zhu X, et al. A highly conserved cryptic epitope in the receptor binding domains of SARS CoV 2 and SARS CoV. Science. 2020;eabb7269.
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